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BiomedicalMitochondrial DysfunctionCommunity Library Mitochondria Dysfunction in Autism Spectrum Disorders: Dr. Suzanne Goh, pediatric neurologist, discusses the link between mitochondrial dysfunction in Autism Spectrum Disorder.
BiomedicalMitochondrial DysfunctionCommunity Library Centers for Disease Control and Prevention: Mitochondrial Disease - Frequently Asked Questions: Some common questions concerning the relationship between mitochondrial disease and autism are answered.
BiomedicalMitochondrial DysfunctionCommunity Library Aluminum Toxicity in Mitochondrial Dysfunction and ASD: Article discusses aluminum and mitochondrial dysfunction.
BiomedicalMitochondrial DysfunctionCommunity Library Evidence of Mitochondrial Dysfunction in Autism and Implications Treatment, Dan Rossignol, MD, and Jeff Bradstreet, MD: This study discusses how in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms.
BiomedicalMitochondrial DysfunctionCommunity Library Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated with Autism Spectrum Disorders, Richard Frye, MD, and Dan Rossignol, MD: Over the past decade, evidence has emerged that some children with ASD suffer from undiagnosed comorbid medical conditions. One of the medical disorders that has been consistently associated with ASD is mitochondrial dysfunction. This article compares the clinical features associated with ASD and mitochondria disorder.
BiomedicalMitochondrial DysfunctionCommunity Library Mitochondrial Dysfunction and Autism Spectrum Disorders: A Simplified Approach, Dan Rossignol, MD, and Richard Frye, MD: The evidence for mitochondrial dysfunction in ASD has expanded over the last several years based on multiple published papers on this topic. This article reviews the role of mitochondria in health and disease, the proper functioning of mitochondria, possible causes of mitochondrial dysfunction in ASD, laboratory testing and criteria that can help identify mitochondrial dysfunction, and potential treatments.
BiomedicalMitochondrial DysfunctionCommunity Library Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis, Dan Rossignol, MD, and Richard Frye, MD: This study suggests children with ASD have a spectrum of mitochondrial dysfunction (MD) of differing severity. Eighteen publications representing a total of 112 children with ASD and MD (ASD/MD) were identified. The prevalence of many of these abnormalities was similar to the general population of children with MD, suggesting that ASD/MD represents a distinct subgroup of children with MD.
BiomedicalMitochondrial DysfunctionCommunity Library Mitochondrial and metabolic abnormalities in neurodevelopmental disorders, Dan Rossignol, MD and Richard Frye, MD: This article addresses the issue that in Autism Spectrum Disorders, physiological abnormalities exist which can be linked to developmental, cognitive and medical disability. In order to improve treatment protocols, it is important to address the significant metabolic abnormalities associated with neuro developmental disorders such as ASD. By Increasing awareness of these underlying metabolic disorders such as mitochondria, cholesterol, BH4 and others, treatment of them will better improve long term outcomes for ASD.
BiomedicalMitochondrial DysfunctionCommunity Library Mitochondrial physiology and autism spectrum disorder, Dan Rossignol, MD and Richard Frye, MD: This critical review provides an overview of mitochondrial function in the context of autism spectrum disorder and a better understanding of the importance of mitochondria as it is related to ASD. This critical review also provides a brief overview of mitochondrial function and its influence on other cellular systems in the context of ASD. Although studies have indicated a prevalence of Mitochondrial disease in ASD, the exact prevalence is most likely underestimated. Recent studies have uncovered novel forms of mitochondrial dysfunction in ASD that may not be readily recognized by classic diagnostic criteria.
BiomedicalMitochondrial DysfunctionCommunity Library Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism, Dan Rossignol, MD and Richard Frye, MD: This manuscript examines the evidence linking oxidative stress, mitochondrial dysfunction and immune dysregulation/inflammation in the brain of ASD individuals, suggesting that ASD has a clear biological basis with features of known medical disorders. This understanding may lead to new testing and treatment strategies in individuals with ASD. Like ASD, inflammation, oxidative stress and mitochondrial dysfunction are seen in a wide range of psychiatric disorders. Oxidative stress may lead to impaired mitochondrial functioning. Further research will be needed.
BiomedicalMitochondrial DysfunctionCommunity Library Bridging the Gap Between Mitochondrial Disease and Autism: This article discusses mitochondrial disease, explores the gap between it and autism, discusses who should be evaluated for mitochondrial disease, and explains the importance of knowing if it is present in the patient with autism.
BiomedicalMitochondrial DysfunctionCommunity Library Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches, by Ning Cheng, Jong M. Rho, and Susan A. Masino : This scientific review paper investigates mitochondrial and metabolic dysfunction and their possible roles in the development of autism spectrum disorders.