Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is associated with or initiated by streptococcal infections. Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is a bigger subset which can include Lyme, Lyme co-infections, chemicals and other possible viruses such as Epstein Barr Virus (EBV), Herpes Simplex, Staph, and Mycoplasma. See the PANDAS Network for more information.
Both disorders are usually characterized by the sudden on-set of symptoms such as OCD (Obsessive Compulsive Disorder), motor tics, abnormal eating behaviors (anorexia), anxiety, mood swings, aggression, cognitive deterioration, sensory and motor abnormalities, irritability and oppositional behaviors. Elevated antibodies and infections signal neuronal cells in the brain which trigger the above symptoms.
Many parents report that their child's sudden aggressive behaviors are unexplainable to medical physicians who are generally not familiar with these disorders. However, what is most important is to make the connection between the neurological behaviors and issues going on with the immune system. Antibodies can be elevated and testing for triggers is essential to determine how to down regulate the immune reactions in order to turn off the activated antibodies to reduce symptoms. Medical treatment protocols for PANDAS and PANS may include: Intravenous Immunoglobulin (IVIG), antibiotics, plasmaphereisis or plasma exchange, steroids, Low Dose Naltrexone, Transfer Factor, or antivirals. The following medical conditions may also contribute to the sudden onset of the manic and psychotic behaviors: Kryptopyrroluria (Pyrrole Disorder), low cholesterol, low lithium levels, low vitamin B12, and low Vitamin D, low Ferritin, hypothyroid, and possible elevated testosterone and other androgens. Talk to your doctor about symptoms, testing, and treatment protocols for the above conditions to gain a better understanding of your child's particular case.
The PANDAS Network
Description: Provides parents with the latest information on PANDAS and PANS including research and resources.
Dear Autism and PANDAS/PANS Researchers - Listen To The Parents
Description: This article contains a small group of parental reports. They are though, a picture of a much bigger issue, an issue that keep research, treatments and causation blocked from very sick children. Parents need true research and studies that can help stop these immune system diseases and in doing so, it must be recognized that autism and PANDAS/PANS are related.
PANDAS, PANS, Penguins and Autism
Description: One family’s story.
International OCD Foundation
Description: This site gives a very comprehensive understanding of PANDAS and PANS.
Some forums require you to sign in to Yahoo or Facebook to locate forum names.
Forum/Blog Name: Strep Infection Associated with ADHD and Autism
Description: PANDAS leads to autoimmune-mediated inflammation of the brain, and usually occurs after several bouts of Strep throat, but may manifest even if the parent cannot recall history of Streptoccal infection in their child.
Forum/Blog Name: PANDAS Parents
Description: This group is open to all PANDAS/PANS parents, however, we differ from other PANDAS/PANS groups by narrowing the focus and limiting the discussion of posts to topics specifically related to traditional PANDAS (triggered by Strep).
Forum/Blog Name: PANDAS/PANS/Lyme/Tick-Borne Diseases
Description: Welcome to PANDAS/PANS/LYME/TICK-BORNE DISEASES, a safe place for parents to come for support & information for their children afflicted with PANDAS/PANS and/or Lyme & Tick-Borne Diseases.
Forum/Blog Name: PANDAS
Description: Welcome to a place where parents and those affected with PANDAS can share information, hope and resources. Anyone affected by or interested in the disease can join.